Merlen J F
Phlebologie. 1982 Apr-Jun;35(2):631-7.
A microvascular "condition" associated with the contraceptive Pill does exist; it explains in those "priviledged" women certain functional symptoms and minor venous incidence such as telangiectasia. We still have to prove the direct and particular relation. Documents and statistics are few and far between ; the reasons for this are the difficulty in obtaining them, the pharmaceutical form, and individual vascular response. A regional investigation was carried out over four years in a homogenous population shows only four cases of telangiectasia. Clinical and experimental facts enable us to discuss the pathogeny. Excessive permeability and capillaro-venular neogenesis are at its basis and, mutatis mutandis, we can compare gravid histangiopathy and functional histangiopathy of the Pill, there being no fibrinoid necrosis. We are able to observe under capillaroscopy the same phenomenon in the base of the nail, as in the ocular conjunctiva: this stems from excessive permeability and its effects of interstitial constriction on the microvessels when the lymphatic drainage is flooded. Corrective treatment is possible.
与避孕药相关的微血管“状况”确实存在；它解释了那些“幸运”女性的某些功能性症状和轻微静脉病变，如毛细血管扩张。我们仍需证明这种直接而特殊的关系。相关文献和统计数据极为稀少，原因在于获取它们存在困难、药物剂型以及个体血管反应。在一个同质人群中进行了为期四年的区域调查，仅发现四例毛细血管扩张病例。临床和实验事实使我们能够探讨其发病机制。其基础是通透性过高和毛细血管后微静脉新生，在作必要变动后，我们可以将孕期组织血管病与避孕药的功能性组织血管病进行比较，不存在纤维蛋白样坏死。我们能够在毛细血管镜下观察到，指甲根部与眼结膜出现相同的现象：这是由于通透性过高以及当淋巴引流受阻时，其对微血管的间质收缩作用所致。矫正治疗是可行的。
