Kol R, Heimer Y M, Green M, Ben-Hur E
Radiat Environ Biophys. 1982;20(3):201-7. doi: 10.1007/BF01325469.
Chinese hamster V79 cells in log-phase were exposed daily to 0.6 Gy of gamma radiation for 3-6 months. After such an exposure the population doubling time increased from 10 to 15 h. When irradiation was discontinued doubling time gradually decreased. Cell survival following acute radiation dose of the low-level irradiated cells remained the same as that of untreated cells. The fractionated irradiation did not affect the capacity of the cells to perform DNA repair synthesis. Likewise, the sensitivity to inhibition by acute radiation exposure of the ability to induce ornithine decarboxylase activity was similar in cells exposed to fractionated irradiation and in untreated cells. It is concluded that there is no apparent effect of sublethal radiation dose received in one generation on the radiation sensitivity of the succeeding generations during the log-phase of growth.
处于对数生长期的中国仓鼠V79细胞每天接受0.6 Gy的γ射线照射，持续3至6个月。经过这样的照射后，群体倍增时间从10小时增加到15小时。当停止照射后，倍增时间逐渐缩短。低水平照射细胞经急性辐射剂量后的细胞存活率与未处理细胞相同。分次照射不影响细胞进行DNA修复合成的能力。同样，分次照射的细胞和未处理的细胞对急性辐射暴露诱导鸟氨酸脱羧酶活性能力的抑制敏感性相似。得出的结论是，在对数生长期，一代细胞接受的亚致死辐射剂量对后代细胞的辐射敏感性没有明显影响。
