三甲沙林（补骨脂素）加近紫外线对中国仓鼠细胞中鸟氨酸脱羧酶诱导的抑制作用。
Inhibition by trioxalen (psoralen) plus near-ultraviolet light of the induction of ornithine decarboxylase in Chinese-hamster cells.
作者信息
Heimer Y M, Riklis E
出版信息
Biochem J. 1979 Oct 1;183(1):179-80. doi: 10.1042/bj1830179.
Abstract
Trioxalen (trimethylpsoralen) plus near-u.v. light, a potent inhibitor of DNA and RNA synthesis, inhibits the induction of ornithine decarboxylase in stationary-phase V79 fibroblasts. It does not affect the translation of pre-existing mRNA. The method, in view of its high degree of specificity and precise timing, is a better choice for inhibiting RNA synthesis than the commonly used chemical inhibitors and precursor analogues.
摘要
三甲沙林（三甲基补骨脂素）加近紫外线，一种有效的DNA和RNA合成抑制剂，可抑制静止期V79成纤维细胞中鸟氨酸脱羧酶的诱导。它不影响预先存在的mRNA的翻译。鉴于其高度的特异性和精确的时间控制，该方法在抑制RNA合成方面比常用的化学抑制剂和前体类似物是更好的选择。
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