Levi F, Halberg F
Ric Clin Lab. 1982 Apr-Jun;12(2):323-70. doi: 10.1007/BF02909422.
A built-in (genetically determined) about-7-day (circaseptan) period comes to the fore as a desynchronized feature of human time structure in the urinary excretion of 17-ketosteroids by a clinical healthy man: during several years following an endocrine intervention (the self-administration of testosterone suppositories), a circaseptan rhythm (which during the preceding decade had revealed a period of precisely 7 days) deviated slightly, yet with statistical significance, from the environmental week. A second line of evidence for an intrinsic circaseptan component stems from the demonstration of statistically significant differences in timing of a circaseptan rhythm in springtail oviposition. A third line of evidence documents prominent circaseptan rhythmicity after the application of a single stimulus (devoid in itself of any circaseptan information). Such single stimulus induction, amplification and/or synchronization also documents the clinical and biologic importance of built-in circaseptan rhythms that were previously often misinterpreted as being purely reactive: a circaseptan spectral component is remarkably prominent in mammalian organ transplant rejection, both in the clinic and in the laboratory. In the latter case, in the absence of any weekly cycles in hospital routine, including treatment schedules, circaseptan components characterize the rejection of the rat kidney, pancreas and heart. Much additional information here reviewed reveals the occurrence of periods of about 7 days. Their implications for transplant and other chronoimmunology as well as biology in general, and their clinical applications in drug treatment, include the need to weld circaseptan timing to circadian timing and dosing. A dramatic documentation of this need stems from the circumstance that pretreatment for one week with the same total dose of the same substance (a polysaccharide - Lentinan) accelerates or retards cancerous growth (hence shortens or lengthens survival) as a function of interactive circaseptan and circadian rhythms.
一名临床健康男性尿中17 - 酮类固醇的排泄情况显示，一种内在的（由基因决定的）约7天（七日周期）的周期作为人类时间结构的去同步特征凸显出来：在内分泌干预（自我服用睾酮栓剂）后的几年里，一个七日周期节律（在前十年中显示周期恰好为7天）与环境周相比略有偏差，但具有统计学意义。支持内在七日周期成分的第二条证据来自于对跳虫产卵时七日周期节律时间的统计学显著差异的证明。第三条证据记录了在施加单一刺激（其本身不包含任何七日周期信息）后显著的七日周期节律性。这种单一刺激诱导、放大和/或同步也证明了先前常常被误解为纯粹是反应性的内在七日周期节律的临床和生物学重要性：在临床和实验室中，七日周期光谱成分在哺乳动物器官移植排斥中都非常突出。在后一种情况下，在医院日常事务（包括治疗计划）中不存在任何每周周期的情况下，七日周期成分表征了大鼠肾脏、胰腺和心脏的排斥反应。这里回顾的许多其他信息揭示了约7天周期的存在。它们对移植和其他时间免疫学以及一般生物学的影响，以及它们在药物治疗中的临床应用，包括需要将七日周期时间与昼夜节律时间和给药相结合。这种需求的一个戏剧性记录源于这样的情况：用相同物质（一种多糖——香菇多糖）的相同总剂量进行一周的预处理，根据相互作用的七日周期和昼夜节律，会加速或延缓癌性生长（从而缩短或延长生存期）。
