耳硬化症和梅尼埃病中的II型胶原自身免疫性。
Type II collagen autoimmunity in otosclerosis and Meniere's Disease.
作者信息
Yoo T J, Stuart J M, Kang A H, Townes A S, Tomoda K, Dixit S
出版信息
Science. 1982 Sep 17;217(4565):1153-5. doi: 10.1126/science.7112122.
PMID:7112122
Abstract
Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations suggest a possible role for type II collagen autoimmunity in the etiology of otosclerosis and Meniere's disease.
摘要
对耳硬化症患者和美尼尔氏病患者检测了抗I型、II型和IV型胶原蛋白的抗体。这些患者体内II型胶原蛋白抗体水平显著高于对照组，而I型或IV型胶原蛋白抗体水平则未发现差异。这些观察结果表明，II型胶原蛋白自身免疫在耳硬化症和美尼尔氏病的病因学中可能发挥作用。
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