II型胶原自身免疫与梅尼埃病。
Type II collagen autoimmunity and Ménière's disease.
作者信息
Herdman R C, Morgan K, Holt P J, Ramsden R T
机构信息
University Department of Otolaryngology, Manchester.
出版信息
J Laryngol Otol. 1993 Nov;107(11):994-8. doi: 10.1017/s0022215100125083.
Antibodies to type II collagen have been reported by some authors to be raised in patients with Ménière's disease. In this study the antibody levels to type I and II collagen have been measured in 37 patients with Ménière's disease and 20 controls, using a solid-phase, double-antibody, enzyme-linked, immunoassay. No significant difference in antibody levels between the two groups was found. These findings do not support previously reported work which suggests that some cases of Ménière's disease are due to type II collagen autoimmunity.
一些作者报告称，梅尼埃病患者体内会产生抗II型胶原蛋白抗体。在本研究中，采用固相双抗体酶联免疫分析法，对37例梅尼埃病患者和20名对照者的I型和II型胶原蛋白抗体水平进行了测定。结果发现，两组之间的抗体水平没有显著差异。这些发现不支持先前报道的研究结果，即某些梅尼埃病病例是由II型胶原蛋白自身免疫引起的。
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