药物性肝损伤
Drug-induced liver injury.
作者信息
Mitchell J R, Lauterburg B H
出版信息
Hosp Pract. 1978 Sep;13(9):95-8, 103-4, 106. doi: 10.1080/21548331.1978.11707401.
PMID:711216
Abstract
In the usual course of events, the liver detoxifies hepatocytotoxic intermediates of drug metabolism. But when protective systems are overloaded by normally harmless drugs, the intermediates can cause massive, even fatal, hepatic necrosis.
摘要
在通常情况下，肝脏会对药物代谢产生的肝细胞毒性中间体进行解毒。但当保护系统被通常无害的药物过度负荷时，这些中间体可导致大规模甚至致命的肝坏死。
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