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人类创伤后长期逆行性皮质脊髓变性

Long term post-traumatic retrograde corticospinal degeneration in man.

作者信息

Bronson R, Gilles F H, Hall J, Hedley-Whyte E T

出版信息

Hum Pathol. 1978 Sep;9(5):602-7. doi: 10.1016/s0046-8177(78)80143-9.

DOI:10.1016/s0046-8177(78)80143-9
PMID:711235
Abstract

The spinal cord and brain of a man who died 18 years after a crush injury of lumbar segments contained some unusual lesions. There was a reduced number of myelinated axons in the corticospinal tracts as high as the fifth cervical segment. Such retrograde degeneration has been described in human pyramidal tracts only a few times. The results of reported studies of experimental retrograde degeneration have been inconsistent. The course of the fasciculus gracilis, as delineated by gliosis, was atypical, and an unusual glial nodule, possibly neoplastic, was present in the dorsal columns at C8.

摘要

一名在腰段挤压伤18年后死亡的男子的脊髓和大脑中存在一些异常病变。在高达颈五节段的皮质脊髓束中,有髓轴突数量减少。这种逆行性变性仅在人类锥体束中被描述过几次。已报道的实验性逆行性变性研究结果并不一致。由胶质细胞增生所勾勒出的薄束走行不典型,并且在颈8节段的后柱中存在一个异常的胶质结节,可能为肿瘤性结节。

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