Albert S A, Shires G T, Illner H, Shires G T
Surg Gynecol Obstet. 1982 Sep;155(3):326-32.
The endorphins appear to play an integral role in the physiopathology of hemorrhagic shock. Blockade of these endodgenous opiates by naloxone can significantly alter the course of this syndrome. While the administration of naloxone to normal rats had no effect upon the circulation or cellular function, it improved the hemodynamic status of rats subjected to hemorrhagic shock, resulting in improved tissue perfusion. In addition, the administration of this drug prevented the cellular dysfunction normally seen in hemorrhagic shock. This effect was independent of its salutary effects upon the circulation.
内啡肽似乎在失血性休克的病理生理过程中发挥着不可或缺的作用。纳洛酮阻断这些内源性阿片类物质可显著改变该综合征的病程。虽然给正常大鼠注射纳洛酮对循环或细胞功能没有影响，但它改善了失血性休克大鼠的血流动力学状态，从而改善了组织灌注。此外，使用这种药物可预防失血性休克中常见的细胞功能障碍。这种作用与其对循环的有益作用无关。
