大剂量吸入特布他林治疗慢性重度哮喘：湿化雾化与储雾罐给药的比较
High-dose inhaled terbutaline in the management of chronic severe asthma: comparison of wet nebulisation and tube-spacer delivery.
作者信息
Prior J G, Nowell R V, Cochrane G M
出版信息
Thorax. 1982 Apr;37(4):300-3. doi: 10.1136/thx.37.4.300.
Abstract
Eight patients with chronic severe asthma, poorly controlled by conventional doses of inhaled bronchodilator, were treated with high-dose inhaled terbutaline (4 mg four times daily), via either wet nebulisation of terbutaline respirator solution, or by tube-spacer aerosol, using cannisters delivering 1 mg terbutaline per metered dose. All patients improved objectively and subjectively on these higher dosage regimens during both day and night. A trial of high-dose inhaled beta2 sympathomimetic therapy should be considered in any patient with chronic severe asthma who fails to obtain benefit from standard doses of inhaled bronchodilator.
摘要
8例慢性重度哮喘患者，使用常规剂量吸入性支气管扩张剂控制不佳，接受高剂量吸入特布他林治疗（每日4次，每次4mg），给药方式为特布他林雾化液湿化雾化，或使用每揿释放1mg特布他林的药罐通过储雾罐进行气溶胶吸入。所有患者在白天和夜间接受这些高剂量治疗方案后，客观和主观症状均有改善。对于任何使用标准剂量吸入性支气管扩张剂治疗无效的慢性重度哮喘患者，均应考虑进行高剂量吸入β2肾上腺素能激动剂治疗试验。
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