Fuxe K, Andersson K, Nilsen O G, Toftgård R, Eneroth P, Gustafsson J A
Toxicol Lett. 1982 Jul;12(2-3):115-23. doi: 10.1016/0378-4274(82)90173-4.
The present study demonstrates reductions of dopamine (DA) turnover in various areas of the anterior nucleus caudate of rat by toluene at concentrations lower than the current OSHA threshold limit value (100 ppm). Thus, toluene at low concentrations may produce disturbances in dopaminergic mechanisms of the basal ganglia probably leading to functional changes in sensory-motor integration. The increases in DA turnover in the cholecystokinin (CCK)-DA terminals of the subcortical limbic system induced by high concentrations of toluene may be part of the neurochemical basis for its abuse as a euphoric agent in man.
本研究表明，低于美国职业安全与健康管理局（OSHA）当前阈限值（100 ppm）的甲苯浓度可降低大鼠尾状前核各区域的多巴胺（DA）周转率。因此，低浓度甲苯可能会干扰基底神经节的多巴胺能机制，可能导致感觉运动整合功能发生变化。高浓度甲苯诱导的皮质下边缘系统胆囊收缩素（CCK）-DA终末中DA周转率增加，可能是其作为一种致欣快剂在人类中被滥用的神经化学基础的一部分。
