Agnati L F, Andersson K, Fuxe K, Benfenati F, Cortelli P, D'Alessandro R, Ogren S O
Adv Biochem Psychopharmacol. 1980;24:75-80.
Catecholamine levels and turnover have been analyzed in DA cell body and in terminal-rich areas of the midbrain, diencephalon, and forebrain 48 hr following a 2-week treatment with l-sulpiride and haloperidol. At this time interval behavioral supersensitivity to DA agonists has been demonstrated. No changes in DA turnover are found in the DA cell body groups A9 and A10 or in various DA terminals of forebrain, with a possible exception for the diffuse type of DA terminals in the tuberculum olfactorium where a reduction of DA turnover rate is observed. In the median eminence of the l-sulpiride-treated group, however, DA turnover increases are observed. It is suggested that the lack of amine turnover changes in most of the DA terminal systems of the brain is related to the development of DA receptor supersensitivity in both striatal and limbic areas, balancing the DA receptor blocking activity of the neuroleptic drugs still present in the tissue of the brain.
在用左旋舒必利和氟哌啶醇进行为期2周的治疗后48小时，对中脑、间脑和前脑富含多巴胺（DA）细胞体及终末的区域的儿茶酚胺水平和周转率进行了分析。在此时间间隔，已证明对DA激动剂存在行为超敏反应。在DA细胞体群A9和A10或前脑的各种DA终末中未发现DA周转率的变化，嗅结节中弥漫型DA终末可能是个例外，在那里观察到DA周转率降低。然而，在左旋舒必利治疗组的正中隆起中，观察到DA周转率增加。有人提出，大脑中大多数DA终末系统中胺周转率缺乏变化与纹状体和边缘区域DA受体超敏反应的发展有关，这平衡了仍存在于脑组织中的抗精神病药物的DA受体阻断活性。
