聚集对小鼠中苯环利定致死性的影响。

The effects of aggregation on the lethality of phencyclidine in mice.

作者信息

Landauer M R, Balster R L

出版信息

Toxicol Lett. 1982 Jul;12(2-3):171-6. doi: 10.1016/0378-4274(82)90181-3.

Abstract

The lethal effects of d-amphetamine and phencyclidine (PCP) were compared when adult male mice were placed into isolated or aggregated (12 mice/cage) conditions. The LD50 of d-amphetamine decreased approx. 30-fold between isolated (87.9 mg/kg) and aggregated (2.8 mg/kg) conditions. In contrast, PCP showed only a 1.3-fold increase in toxicity between isolated (64.5 mg/kg) and aggregated (48.4 mg/kg) conditions. These results suggest different mechanisms for the acute lethal effects of d-amphetamine and PCP in mice.

摘要

当成年雄性小鼠被置于单独饲养或群居（每笼12只）条件下时，比较了右旋苯丙胺和苯环己哌啶（PCP）的致死效应。右旋苯丙胺的半数致死量（LD50）在单独饲养（87.9毫克/千克）和群居（2.8毫克/千克）条件下降低了约30倍。相比之下，PCP在单独饲养（64.5毫克/千克）和群居（48.4毫克/千克）条件下毒性仅增加了1.3倍。这些结果表明，右旋苯丙胺和PCP对小鼠的急性致死效应存在不同机制。