酸性和碱性脱氧核糖核酸酶作为泌尿生殖道癌症肿瘤标志物的作用。

The role of acid and alkaline DNases as tumour markers in cancer of the genitourinary tract.

作者信息

Lykourinas M, Constantinidis C, Spantidos A, Manthopoulos A, Dimopoulos C

出版信息

Urol Res. 1982;10(2):67-70. doi: 10.1007/BF00262404.

Abstract

The levels of Acid and Alkaline DNases were measured in the serum of patients with: (a) Cancer of the Genitourinary Tract (confirmed by biopsy), (b) with inflammatory diseases and non-malignant tumours of the Genitourinary tract, (c) healthy blood donors. In the first group the results showed that the Acid DNase level was raised in 62% and Alkaline DNase in 43%. In the second group acid DNase was increased in 30% and Alkaline DNase in 13%. In the third group Acid and Alkaline DNase levels were normal. These results suggest that the measurement of Acid and Alkaline DNases could be considered as malignant diseases markers, in spite of false positive and false negative results in some cases.

摘要

对以下患者血清中的酸性和碱性脱氧核糖核酸酶水平进行了测量

（a）经活检确诊的泌尿生殖道癌症患者；（b）患有泌尿生殖道炎症性疾病和非恶性肿瘤的患者；（c）健康献血者。在第一组中，结果显示62%的患者酸性脱氧核糖核酸酶水平升高，43%的患者碱性脱氧核糖核酸酶水平升高。在第二组中，30%的患者酸性脱氧核糖核酸酶升高，13%的患者碱性脱氧核糖核酸酶升高。在第三组中，酸性和碱性脱氧核糖核酸酶水平正常。这些结果表明，尽管在某些情况下存在假阳性和假阴性结果，但酸性和碱性脱氧核糖核酸酶的测量仍可被视为恶性疾病的标志物。