人血清白蛋白的两种新的缓慢移动变体。

Two new slow-moving variants of human serum albumin.

作者信息

Nishimukai H, Kera Y, Sano Y, Sakata K, Kitamura H, Tsukamoto K, Yamasawa K

出版信息

Vox Sang. 1982;42(6):313-7. doi: 10.1111/j.1423-0410.1982.tb01105.x.

DOI:10.1111/j.1423-0410.1982.tb01105.x

Abstract

Two new slow-moving variants of human serum albumin were found in members of two unrelated Japanese families. These variants, different from each other and from the slow-moving variants described previously, were designated albumin "Okinoerabu' and albumin "Akasaka'. The mode of inheritance of each variant was consistent with an autosomal codominant trait. A very rare type, homozygote for a variant, albumin "Okinoerabu', was also detected. The segregation data of albumin and Gc showed no discrepancy from the postulation of a linkage between these two loci.

摘要

在两个没有亲缘关系的日本家族成员中发现了两种新的慢速移动的人血清白蛋白变体。这些变体彼此不同，也与先前描述的慢速移动变体不同，被命名为白蛋白“冲永良部”和白蛋白“赤坂”。每个变体的遗传模式与常染色体共显性性状一致。还检测到一种非常罕见的类型，即变体白蛋白“冲永良部”的纯合子。白蛋白和Gc的分离数据与这两个基因座之间存在连锁关系的假设没有差异。