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胃和十二指肠溃疡行选择性近端迷走神经切断术后的胃黏膜

Gastric mucosa after selective proximal vagotomy at stomach and duodenal ulcers.

作者信息

Zufarov K A, Rasulev K I

出版信息

Z Mikrosk Anat Forsch. 1982;96(2):346-60.

PMID:7113344
Abstract

Biopsies obtained from gastric fundus of 25 patients suffering from gastric and duodenal ulcers, before and after (from 3 months to 2 years) selective proximal vagotomy with pyloroplastics were studied. The general morphologic, electron microscopic, histochemical and cytochemical methods revealed that selective proximal vagotomy caused nonspecific hemodynamic alterations in gastric mucosa, these alterations being observed during 3 postoperative months. In the following period the general morphology of gastric mucosa was predominantly identical to that in preoperative periods. Quantitative and functional activity of parietal and peptic cells were reduced both in the early and later periods of investigation, that being confirmed by lowering of acid and enzymes output after vagotomy. The mucous-producing function of gastric mucosa was unchanged.

摘要

对25例胃和十二指肠溃疡患者在选择性近端迷走神经切断术加幽门成形术前及术后(3个月至2年)取自胃底的活检组织进行了研究。常规形态学、电子显微镜、组织化学和细胞化学方法显示,选择性近端迷走神经切断术引起胃黏膜非特异性血流动力学改变,这些改变在术后3个月内可见。在随后的时期,胃黏膜的总体形态与术前基本相同。在研究的早期和后期,壁细胞和主细胞的数量及功能活性均降低,迷走神经切断术后胃酸和酶分泌减少证实了这一点。胃黏膜的黏液分泌功能未改变。

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