抗风湿药物对肝脏培养物中胶原分解组织蛋白酶活性的影响。
Influence of anti-rheumatic drugs on the activity of collagenolytic cathepsin in hepatic culture.
作者信息
Kucharz E, Stawiarska B, Drozdz M
出版信息
Acta Biol Med Ger. 1982;41(1):39-46.
PMID:7113547
Abstract
A decrease of the collagenolytic cathepsin activity was found in foetal and adult hepatic slices cultured in vitro with acetylsalicylic acid, phenylbutazone, aminophenazone, indomethacin and naproxen. The most marked decrease was found in slices treated with naproxen and indomethacin. Acetylsalicylic acid produced only a slight diminution of the enzyme activity. Studies on hepatotoxicity indicated that acetylsalicylic acid and phenylbutazone are very toxic drugs, whereas the naproxen toxicity was very low.
摘要
在体外培养的胎儿和成人肝脏切片中，用乙酰水杨酸、保泰松、氨基比林、吲哚美辛和萘普生处理后，发现胶原分解组织蛋白酶活性降低。在用萘普生和吲哚美辛处理的切片中发现活性降低最为明显。乙酰水杨酸仅使酶活性略有降低。肝毒性研究表明，乙酰水杨酸和保泰松是毒性很强的药物，而萘普生的毒性很低。
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Influence of anti-rheumatic drugs on the activity of collagenolytic cathepsin in hepatic culture.抗风湿药物对肝脏培养物中胶原分解组织蛋白酶活性的影响。
Acta Biol Med Ger. 1982;41(1):39-46.
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