Kucharz E J, Hawryiuk D
Pharmazie. 1987 Feb;42(2):117-8.
Rats were treated acetylosalicylic acid (150 mg/kg b.w.) or naproxen (125 mg/kg b.w.) during 6 weeks. An increase of collagen content, elevated solubility of collagen and changes in the ratio of type I to type III collagen were observed in animals receiving acetylosalicylic acid, and only slight alterations were found in these treated with naproxen. A rise of indices of the liver injury in blood serum was shown after treatment with acetylosalicylic acid. It is suggested that changes of collagen metabolism in the liver of rats receiving anti-rheumatic drugs are caused by direct action of the drugs on collagen biosynthesis and catabolism as well as resulted from the toxic action of the drugs on the liver.
大鼠连续6周接受乙酰水杨酸（150毫克/千克体重）或萘普生（125毫克/千克体重）治疗。在接受乙酰水杨酸治疗的动物中，观察到胶原蛋白含量增加、胶原蛋白溶解度升高以及I型与III型胶原蛋白比例的变化，而接受萘普生治疗的动物仅出现轻微改变。乙酰水杨酸治疗后血清中肝损伤指标升高。提示接受抗风湿药物治疗的大鼠肝脏中胶原蛋白代谢的变化是药物对胶原蛋白生物合成和分解代谢的直接作用以及药物对肝脏的毒性作用所致。
