Asakawa K, Takano K, Kogawa M, Hasumi Y, Shizume K
Acta Endocrinol (Copenh). 1982 Jun;100(2):206-10. doi: 10.1530/acta.0.1000206.
Serum levels of somatomedin A, as measured by radioreceptor assay, and body weight gain were 86.5 +/- 9.2% and 166.9 +/- 7.8% (N = 5) of the initial values, respectively, after 18 days administration of 2.5 mg cortisone acetate (CA). These values were significantly lower than those for saline treated rats (P less than 0.005). Reduced serum somatomedin A and body growth rate were partially restored after halting the injection of CA. Combined administration of daily doses of 100 micrograms hGH with CA did not prevent the decrease in somatomedin activity in treated rats. This observation suggests that GH plays a minor (or no) role in the fall of serum somatomedin A in CA-treated rats. From these data we conclude that glucocorticoids reduce serum somatomedin by inhibiting the effect of GH on the generation of somatomedin.
通过放射受体分析法测定，在给予2.5毫克醋酸可的松（CA）18天后，血清生长调节素A水平和体重增加分别为初始值的86.5±9.2%和166.9±7.8%（N = 5）。这些值显著低于生理盐水处理的大鼠（P < 0.005）。停止注射CA后，血清生长调节素A降低和身体生长速率下降的情况得到部分恢复。每日剂量100微克人生长激素（hGH）与CA联合给药并不能防止治疗大鼠中生长调节素活性的降低。这一观察结果表明，生长激素在CA处理的大鼠血清生长调节素A下降中起次要（或无）作用。从这些数据我们得出结论，糖皮质激素通过抑制生长激素对生长调节素生成的作用来降低血清生长调节素。
