Ohmori M, Kobayashi S, Ohtsuki Y, Ogawa K
Acta Pathol Jpn. 1982 Jul;32(4):649-56. doi: 10.1111/j.1440-1827.1982.tb02066.x.
A report is made of a 65-year-old male who died of a malignant hyperthermia of 42 degrees C. Symptoms included muscle rigidity at the termination of operation for neck-clipping of an aneurysm of the anterior communicating artery. Latent myopathy was observed in skeletal muscle, and a bleeding focus was present in the left anterior region of the hypothalamus, coinciding with the temperature regulation center. The mechanism of onset of this disease is still poorly understood, but it seems that this disease occurred due to synergic effects of the hypothalamic hemorrhage and the pre-existing myopathy. The serum CPK level at the time of death was abnormally high (250 U), and 3.4% of isozyme CPK1 was detected. The serum myoglobin was 204, 850 ng/ml, a markedly high level, and myoglobinuric nephrosis was present as a result.
报告了一名65岁男性，死于体温42摄氏度的恶性高热。症状包括在进行前交通动脉瘤夹闭术结束时出现肌肉僵硬。在骨骼肌中观察到潜在的肌病，并且在下丘脑左前区域存在一个出血灶，与体温调节中枢一致。这种疾病的发病机制仍知之甚少，但似乎这种疾病是由于下丘脑出血和先前存在的肌病的协同作用而发生的。死亡时血清肌酸磷酸激酶（CPK）水平异常高（250 U），并检测到3.4%的同工酶CPK1。血清肌红蛋白为204850 ng/ml，处于明显高水平，结果出现了肌红蛋白尿性肾病。
