Giampietro O, Clerico A, Buzzigoli G, Del Chicca M G, Boni C, Carpi A
Horm Res. 1984;19(4):232-42. doi: 10.1159/000179893.
An accurate and close follow-up of serum levels of thyroid hormones and various muscle markers (myoglobin, creatine kinase and its isoenzymes CK-MB and CK-BB, lactic dehydrogenase, alpha-hydroxybutyric dehydrogenase, etc.) was carried out in 10 hypothyroid patients on replacement therapy. The main muscle markers, creatine kinase and myoglobin, were elevated respectively in 9 and 6 subjects. In 1 male significant CK-MB traces were measured, while in 1 woman significant CK-BB amounts were assayed. Significant correlations between patients' thyroid hormones and the levels of the muscle parameters were found. The rate of normalization of thyroid hormones and muscle markers in relation to replacement therapy was also studied. Myoglobin and creatine kinase have proved to be the best indicators of the hypothyroid myopathy, since they are sensitive for the early detection of muscle involvement due to the metabolic disorder and are closely correlated to the metabolic conditions of patients.
对10名接受替代治疗的甲状腺功能减退患者进行了甲状腺激素水平以及各种肌肉标志物（肌红蛋白、肌酸激酶及其同工酶CK-MB和CK-BB、乳酸脱氢酶、α-羟丁酸脱氢酶等）的精确密切随访。主要肌肉标志物肌酸激酶和肌红蛋白分别在9名和6名受试者中升高。在1名男性中检测到显著的CK-MB痕迹，而在1名女性中检测到显著的CK-BB量。发现患者的甲状腺激素与肌肉参数水平之间存在显著相关性。还研究了甲状腺激素和肌肉标志物相对于替代治疗的正常化率。肌红蛋白和肌酸激酶已被证明是甲状腺功能减退性肌病的最佳指标，因为它们对早期检测代谢紊乱引起的肌肉受累敏感，并且与患者的代谢状况密切相关。
