Hicks M J, Heick M, Finley P, Gall E P, Minnich L, Williams R J
Am J Clin Pathol. 1982 Sep;78(3):342-5. doi: 10.1093/ajcp/78.3.342.
The purpose of this study was to evaluate, prospectively, the clinical usefulness of the rate nephelometric method for determining rheumatoid factor (RF) activity, measured in International Units (IU), in patients with rheumatoid arthritis. These results were compared with those of standard latex agglutination titration. The overall correlation between clinical activity and RF activity measured by rate nephelometry and serologic titration are similar, i.e., r = 0.47 (P less than 0.001) and r = 0.43 (p less than 0.001), respectively. However, on an individual patient basis, the nephelometric determination appears to correlate better with disease activity and response to therapy than do titers. The RF activity measured in IU would give the clinician a more sensitive and precise tool with which to follow RF activity in individual patients with active disease.
本研究的目的是前瞻性地评估速率散射比浊法在测定类风湿性关节炎患者类风湿因子（RF）活性（以国际单位（IU）衡量）方面的临床实用性。将这些结果与标准乳胶凝集滴定法的结果进行比较。通过速率散射比浊法和血清学滴定法测得的临床活性与RF活性之间的总体相关性相似，分别为r = 0.47（P<0.001）和r = 0.43（p<0.001）。然而，在个体患者层面，散射比浊法测定结果似乎比滴度测定结果与疾病活动度及治疗反应的相关性更好。以IU为单位测定的RF活性将为临床医生提供一个更敏感、精确的工具，用以跟踪活动性疾病个体患者的RF活性。
