Gagnon J A, Felipe I, Nelson L D, Butkus D E
Am J Physiol. 1982 Sep;243(3):F265-70. doi: 10.1152/ajprenal.1982.243.3.F265.
The influence of thiopental anesthesia on renal tubular sodium reabsorption was investigated in the well-trained dog. After administration of the anesthetic, renal sodium reabsorption was depressed, leading to the enhanced excretion of sodium and water. Associated with this response was a decrease in the plasma levels of epinephrine and norepinephrine. Neither renal hemodynamic functions nor the humoral factors, prostaglandin E, plasma renin activity, or arginine vasopressin appeared to be the major determinants of the natriuresis. These observations suggest that the administration of thiopental depresses renal sympathetic nerve activity, thereby diminishing the renal tubular transport of sodium.
在训练有素的犬身上研究了硫喷妥钠麻醉对肾小管钠重吸收的影响。给予麻醉剂后，肾钠重吸收受到抑制，导致钠和水的排泄增加。与此反应相关的是肾上腺素和去甲肾上腺素血浆水平的降低。肾血流动力学功能和体液因子、前列腺素E、血浆肾素活性或精氨酸加压素似乎都不是钠利尿的主要决定因素。这些观察结果表明，硫喷妥钠的给药会抑制肾交感神经活动，从而减少肾小管对钠的转运。
