Bencsáth P, Kottra G, Takács L
Pflugers Arch. 1983 Jun;398(1):60-3. doi: 10.1007/BF00584714.
The possible role of peritubular capillary physical forces in the diuretic-natriuretic effects of chronic renal denervation was investigated in Inactin-anaesthetized nondiuretic control (C) and unilaterally denervated (D) rats. Micropuncture techniques were combined with measurement of intratubular and peritubular capillary hydrostatic pressures and afferent and efferent arteriolar plasma oncotic pressures were determined, as well. Compared to data of C rats and of innervated kidneys, marked denervation diuresis and natriuresis were seen without changes in GFR. Both late proximal and early distal (F/P)In values were significantly lower in D kidneys with similar SNGFR. Afferent (pia) and efferent (pi e) arteriolar oncotic pressures were unchanged by denervation (C-pi a = 23.3 +/- 0.79, pi e = 29.9 +/- 0.87 mm Hg; D-pi a = 23.2 +/- 0.94, pi e = 29.8 +/- 1.04 mm Hg). Proximal intratubular hydrostatic pressure was moderately but significantly higher in D kidneys (C = 11.9 +/- 0.5, D = 13.7 +/- 0.3 mm Hg, P less than 0.01), while peritubular capillary pressures were: efferent arteriole (C = 13.9 +/- 0.5, D = 13.4 +/- 0.6 mm Hg, NS). It is concluded that the tubular effects of chronic renal sympathectomy are not dependent on changes in Starling forces of the peritubular environment.
在使用Inactin麻醉的非利尿对照（C）大鼠和单侧去神经支配（D）大鼠中，研究了肾小管周围毛细血管物理力在慢性肾去神经支配的利尿利钠作用中的可能作用。将微穿刺技术与肾小管内和肾小管周围毛细血管静水压的测量相结合，并测定了入球和出球小动脉血浆胶体渗透压。与C组大鼠和有神经支配的肾脏的数据相比，在肾小球滤过率（GFR）无变化的情况下，出现了明显的去神经支配利尿和利钠作用。在单肾肾小球滤过率（SNGFR）相似的D组肾脏中，近端小管晚期和远端小管早期的（F/P）In值均显著降低。去神经支配对入球（pia）和出球（pie）小动脉胶体渗透压无影响（C组：pia = 23.3±0.79，pie = 29.9±0.87 mmHg；D组：pia = 23.2±0.94，pie = 29.8±1.04 mmHg）。D组肾脏近端肾小管静水压适度但显著升高（C组 = 11.9±0.5，D组 = 13.7±0.3 mmHg，P＜0.01），而肾小管周围毛细血管压力为：出球小动脉（C组 = 13.9±0.5，D组 = 13.4±0.6 mmHg，无显著差异）。得出的结论是，慢性肾交感神经切除术的肾小管效应不依赖于肾小管周围环境的Starling力变化。
