Golan J, Anaise D, Eylath U, Ben-Hur N
Ann Plast Surg. 1982 May;8(5):397-402. doi: 10.1097/00000637-198205000-00007.
A retrospective study was performed of 512 patients suffering from primary cutaneous malignant melanoma of the skin who had been treated in Israel between 1960 and 1970. The patients were randomly admitted to six hospitals and treated according to different protocols, based on the policy of each hospital. Our conclusions are that in stage I of the disease, radical prophylactic lymph-node dissection (RPLND) improved the prognosis in all three levels of tumor invasion into the skin; in stage II of the disease, RPLND did not improve the prognosis when compared to wide excision of the tumor and excision of the clinically involved nodes; and in stage I of the disease, there is no statistically significant difference in prognosis between excisional biopsy and wide excision of the tumor.
对1960年至1970年间在以色列接受治疗的512例原发性皮肤恶性黑色素瘤患者进行了一项回顾性研究。这些患者被随机收治到六家医院，并根据每家医院的政策按照不同方案进行治疗。我们的结论是，在疾病的I期，根治性预防性淋巴结清扫术（RPLND）改善了肿瘤侵犯皮肤的所有三个层次的预后；在疾病的II期，与广泛切除肿瘤和切除临床受累淋巴结相比，RPLND并未改善预后；而在疾病的I期，切除活检与广泛切除肿瘤之间的预后在统计学上无显著差异。
