Antipenko V P, Krasil'nikov A P
Antibiotiki. 1982 Jun;27(6):450-5.
Resistance of 1060 Enterobacteria strains isolated from patients with chronic pneumonia and bronchitis was studied with respect to 15--18 antibiotics. The methods of agar dilution and sensitivity discs (Pr. mirabilis) were used. High resistance of the isolates to the antibiotics except aminoglycosides was shown. The rate, spectrum and level of the resistance were variable and changed depending on the bacterial species and drug type. The majority (77.7--100 per cent) was multiple resistant (to at least 6--10 antibiotics). The Enterobacteria populations of the respiratory origin were heterogeneous with respect to the resistance warts (61.5--85.7 per cent). The changes included elimination of the primary warts, appearance of new secondary warts or complete replacement of the variant composition. Rational therapy requires investigation of both the species and the variant composition of the microbiocenoses of the bronchial contents and their changes during the patient treatment in the hospital.
对从慢性肺炎和支气管炎患者中分离出的1060株肠杆菌进行了15 - 18种抗生素的耐药性研究。采用琼脂稀释法和药敏纸片法（奇异变形杆菌）。结果显示，除氨基糖苷类抗生素外，分离菌株对其他抗生素具有高度耐药性。耐药率、耐药谱和耐药水平各不相同，并因细菌种类和药物类型而异。大多数（77.7% - 100%）为多重耐药（对至少6 - 10种抗生素耐药）。呼吸道来源的肠杆菌群体在耐药疣方面具有异质性（61.5% - 85.7%）。这些变化包括原发性疣的消除、新的继发性疣的出现或变体组成的完全替代。合理的治疗需要对支气管内容物微生物群落的种类和变体组成及其在患者住院治疗期间的变化进行研究。
