Hoeprich P D, Wolfe B M, Jerome C, Olson D A, Huston A C
Antimicrob Agents Chemother. 1982 Jun;21(6):976-8. doi: 10.1128/AAC.21.6.976.
Long-term, intermittent, intravenous infusion of substances, such as amphotericin B, with a high potential for causing peripheral vein thrombophlebitis was feasible by means of a subcutaneously implanted silastic reservoir catheter device, which gave access to the central venous compartment. The implanted reservoirs withstood at least 100 percutaneous entries with a 27-gauge needle; injections were carried out by using an infusion pump. With precautions taken to prevent infection, clotting, or the formation of precipitates in the catheter, the device permitted easy intravenous injection and was well tolerated.
长期、间歇性静脉输注具有较高外周静脉血栓性静脉炎风险的物质（如两性霉素B），通过皮下植入的硅橡胶贮液器导管装置是可行的，该装置可进入中心静脉腔。植入的贮液器能耐受至少100次使用27号针头的经皮穿刺；注射通过输液泵进行。采取预防措施防止导管感染、凝血或沉淀物形成，该装置便于静脉注射且耐受性良好。
