Moss P D
Arch Dis Child. 1982 Aug;57(8):616-21. doi: 10.1136/adc.57.8.616.
Sixty children who survived meningitis during the outbreak of meningococcal group B infection in Bolton 1971-74 were assessed between 5 and 9 years later. Each case, together with a matched control, has been examined clinically and subjected to a number of psychological tests and to routine audiology. The results, unlike those from other series, did not demonstrate any incoordination, ataxia, or other physical abnormality, nor was there any statistically significant impairment on psychological testing. The incidence of sensorineural deafness (5%), although marginally lower, was comparable with the best of other series. When compared with the incidence in controls (3%) it is not statistically significant. A 'mattress test', suggestive of vestibular damage, was positive in those with more severe degrees of sensorineural deafness. The high mortality in the Bolton series (17%) has been reconsidered and it is concluded that unless a potent meningococcus type B vaccine is developed, mortality would still be high in a similar outbreak today.
对1971年至1974年在博尔顿爆发的B群脑膜炎球菌感染期间存活下来的60名儿童,在5至9年后进行了评估。对每个病例及其配对对照进行了临床检查,并进行了多项心理测试和常规听力检查。与其他系列研究结果不同,本研究结果未显示出任何不协调、共济失调或其他身体异常,心理测试也未发现任何具有统计学意义的损害。感音神经性耳聋的发生率为5%,虽然略低,但与其他最佳系列研究结果相当。与对照组3%的发生率相比,差异无统计学意义。一项提示前庭损伤的“床垫试验”,在感音神经性耳聋程度较重的患者中呈阳性。对博尔顿系列研究中的高死亡率(17%)进行了重新审视,得出的结论是,除非研发出有效的B型脑膜炎球菌疫苗,否则在如今类似的疫情爆发中,死亡率仍将很高。