de la Fuente M, Alía M
Arch Int Pharmacodyn Ther. 1982 May;257(1):168-76.
Four groups of pregnant Wistar rats were injected intraperitoneally at day 7, 10, 13 or 15 of gestation. Every lot in each group received either 10, 20, 30 or 50 mg/kg cyproheptadine. A fifth group received 2 mg/kg/day of this drug during the entire course of pregnancy. The maximum effect of this drug was found on the 13th and 15th day of gestation. The abnormalities observed in the 21 day old foetuses of the first generation (F1) were found mainly in the brain, kidney, liver as well as in the skull and sternum. Cyproheptadine produced post-natal mortality during the first month from 28.8 to 67.8%. The higher degree of mortality was produced in the rats receiving 2 mg/kg/day. The survivors of this F1 generation were treated in the same way as the parent generation (P). Their descendants (F2) showed similar results. Thus cyproheptadine, in all doses administered, produced signs of toxicity and/or teratogenic effects in rats.
将怀孕的Wistar大鼠分为四组，分别在妊娠第7天、第10天、第13天或第15天进行腹腔注射。每组中的每一批大鼠接受10、20、30或50毫克/千克的赛庚啶。第五组在整个孕期接受2毫克/千克/天的该药物。发现该药物在妊娠第13天和第15天产生的影响最大。在第一代（F1）21日龄胎儿中观察到的异常主要出现在脑、肾、肝以及颅骨和胸骨中。赛庚啶在出生后的第一个月导致28.8%至67.8%的死亡率。接受2毫克/千克/天的大鼠死亡率更高。这一代F1的存活者接受与亲代（P）相同的处理方式。它们的后代（F2）显示出相似的结果。因此，在所有给药剂量下，赛庚啶在大鼠中均产生了毒性和/或致畸作用迹象。
