de la Fuente del Rey M
Biol Neonate. 1986;49(3):150-7. doi: 10.1159/000242525.
Five groups of pregnant Wistar rats were injected intraperitoneally with a single dose of semicarbazide (SC) on day 5, 7, 10, 13, or 15 of gestation. The lots in each group received either 50, 75, 100 or 150 mg/kg SC. A sixth group received 17 mg/kg of the drug during the entire course of pregnancy. SC produced a significantly smaller number of live fetuses with respect to controls. This toxic effect after injection at days 7 and 10 of gestation was highest for all single doses. The mean of fetal weight decreased with respect to controls with almost all of the SC treatment studied. The number of implantations and live fetuses was significantly decreased in the rats receiving the continuous treatment. Most abnormalities in the 21-day-old fetuses were found in the brain, kidney, intestines and liver; skeletal anomalies were seen in the skull, sternum and ribs. SC also produced high postnatal mortality rates during the first month of life with the single doses as well as with the continuous treatment. Thus, SC produced signs of toxicity and/or teratogenic effects in rats with all doses administered.
将五组怀孕的Wistar大鼠在妊娠第5、7、10、13或15天腹腔注射单剂量的氨基脲（SC）。每组大鼠分别接受50、75、100或150mg/kg的SC。第六组在整个孕期接受17mg/kg的该药物。与对照组相比，SC导致存活胎儿的数量显著减少。在妊娠第7天和第10天注射后，所有单剂量的这种毒性作用最高。几乎所有研究的SC处理组中，胎儿体重均值相对于对照组均下降。接受连续处理的大鼠中，着床和存活胎儿的数量显著减少。在21日龄胎儿中，大多数异常出现在脑、肾、肠和肝脏；颅骨、胸骨和肋骨出现骨骼异常。单剂量以及连续处理的SC在出生后第一个月也产生了较高的死亡率。因此，所有给药剂量的SC在大鼠中均产生了毒性和/或致畸作用迹象。
