Piran N, Bigler E D, Cohen D
Arch Gen Psychiatry. 1982 Sep;39(9):1006-10. doi: 10.1001/archpsyc.1982.04290090016004.
The performance of 26 young patients with early-onset schizophrenia on motoric laterality and eye dominance was compared with that of 24 psychiatric inpatients suffering from an early and diffuse brain damage, 16 nonpsychotic non-brain-damaged psychiatric inpatients, and 36 university students. All subjects were in late adolescence. These schizophrenic patients showed more left-sidedness on all the laterality measures. Left eye dominance was highly prevalent in the schizophrenic group (about 75% of the subjects) and had high diagnostic usefulness. In addition, laterality measures of the schizophrenic patients were highly incongruous. Our results support the hypothesis of a specific left hemispheric dysfunction in schizophrenia that is neither shared by all psychiatric patients nor resembles a generalized insult to the brain. Although the left hemispheric dysfunction in schizophrenia is considered to be neurological, the etiological contributions of brain insults and of genetic and environmental factors are unclear.
将26例早发性精神分裂症年轻患者的运动偏侧性和眼优势表现与24例患有早期弥漫性脑损伤的精神科住院患者、16例非精神病性非脑损伤精神科住院患者以及36名大学生进行了比较。所有受试者均处于青春期后期。这些精神分裂症患者在所有偏侧性测量中表现出更多的左侧性。左眼优势在精神分裂症组中非常普遍（约75%的受试者），并且具有较高的诊断价值。此外，精神分裂症患者的偏侧性测量结果高度不一致。我们的结果支持精神分裂症存在特定左半球功能障碍的假设，这种功能障碍既不为所有精神科患者所共有，也不类似于对大脑的普遍性损伤。尽管精神分裂症中的左半球功能障碍被认为是神经性的，但脑损伤以及遗传和环境因素的病因学作用尚不清楚。
