Karn R C, Dlouhy S R, Springer K R, Hjorth J P, Nielsen J T
Biochem Genet. 1982 Jun;20(5-6):493-504. doi: 10.1007/BF00484700.
This report describes a gene which influences the electrophoretic mobility of a protein in the salivas of adult mice. Three categories of phenotype have been observed: the two single-banded types, F (Fast) and S (Slow), and the two-banded type, SF (Slow-Fast), with the two bands represented in varying proportions. All females, regardless of age or strain, and all males before puberty show only the F phenotype. Males of the BALB/c and C57BL/6J strains show the F phenotype throughout puberty and adult life, whereas males of the C3H/St and C57BL/KsJ strains show the SF phenotype in puberty and the S phenotype in adult life. We have designated this variation the sex-limited saliva pattern (Ssp). The results from genetic crosses indicate that the variation among the strains is determined by an autosomal locus, Ssp, with two alleles, SspS and SspF, where SspS is dominant to SspF. Testosterone treatment can accelerate the acquisition of the S type in males of the strains C3H/St and C57BL/KsJ and also induces that phenotype in C3H/St females and C57BL/6J males. Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene.
本报告描述了一个影响成年小鼠唾液中蛋白质电泳迁移率的基因。已观察到三类表型：两种单带型，即F（快）和S（慢），以及双带型，即SF（慢 - 快），两条带以不同比例呈现。所有雌性，无论年龄或品系如何，以及所有青春期前的雄性仅表现出F表型。BALB/c和C57BL/6J品系的雄性在整个青春期和成年期都表现出F表型，而C3H/St和C57BL/KsJ品系的雄性在青春期表现出SF表型，在成年期表现出S表型。我们将这种变异命名为性别限制唾液模式（Ssp）。遗传杂交的结果表明，品系间的变异由一个常染色体位点Ssp决定，有两个等位基因，SspS和SspF，其中SspS对SspF呈显性。睾酮处理可加速C3H/St和C57BL/KsJ品系雄性获得S型，还可诱导C3H/St雌性和C57BL/6J雄性出现该表型。因此，观察到的品系特异性差异似乎反映了雄激素水平和/或雄激素敏感性的遗传变异，而非结构基因的变异。
