小鼠腮腺分泌蛋白的遗传及其在确定唾液淀粉酶定量变异体中的应用。
Inheritance of a parotid secretory protein in mice and its use in determining salivary amylase quantitative variants.
作者信息
Owerbach D, Hjorth J P
出版信息
Genetics. 1980 May;95(1):129-41. doi: 10.1093/genetics/95.1.129.
Abstract
Among inbred strains of mice, a major protein, PSP, produced and secreted by the parotid glands, shows variation in electrophoretic mobility and in the peptides produced by cyanogen bromide treatment. This variation is inherited as a single Mendelian factor with two alleles showing co-dominant expression. In genetic crosses, it segregates independently from the amylase complex and is closely linked to the agouti locus on chromosome 2. The protein ratios between amylase and PSP in saliva, obtained by scanning of electrophoretic gel separations, were found to reflect genetic differences in salivary amylase production in strains YBR/Cv and C3H/As.
摘要
在近交系小鼠中，腮腺产生并分泌的一种主要蛋白质PSP，在电泳迁移率以及经溴化氰处理产生的肽方面存在变异。这种变异作为一个单一孟德尔因子遗传，两个等位基因表现为共显性表达。在遗传杂交中，它与淀粉酶复合体独立分离，并与2号染色体上的刺鼠基因座紧密连锁。通过扫描电泳凝胶分离得到的唾液中淀粉酶与PSP的蛋白质比率，被发现反映了YBR/Cv和C3H/As品系唾液淀粉酶产生的遗传差异。
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