支原体诱导的兔慢性关节炎。III. 用非活的关节炎支原体抗原诱导
Chronic arthritis of rabbits induced by mycoplasmas. III. Induction with nonviable Mycoplasma arthritidis antigens.
作者信息
Washburn L R, Cole B C, Ward J R
出版信息
Arthritis Rheum. 1982 Aug;25(8):937-46. doi: 10.1002/art.1780250805.
Preexposure of rabbits to Mycoplasma arthritidis predisposed them to subsequent development of chronic inflammation in knee joints challenged with nonviable M arthritidis antigens. Rabbits sensitized by hyperimmunization developed a more severe arthritis than those sensitized by infection. Unsensitized rabbits responded minimally to intraarticular injection of nonviable organisms. These results suggested that an immune response to a persisting mycoplasmal antigen might be capable of sustaining chronic inflammation in rabbits with arthritis induced by viable M arthritidis.
将兔预先暴露于关节炎支原体，会使它们在受到无活性关节炎支原体抗原攻击的膝关节中更易发生慢性炎症。通过超免疫致敏的兔比通过感染致敏的兔患更严重的关节炎。未致敏的兔对关节内注射无活性微生物的反应极小。这些结果表明，对持续存在的支原体抗原的免疫反应可能能够维持由活性关节炎支原体诱导的兔关节炎中的慢性炎症。
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