3-溴-2-酮戊二酸：二磷酸吡啶核苷酸依赖性异柠檬酸脱氢酶的底物和亲和标记物。 - Suppr | 超能文献

3-Bromo-2-ketoglutarate: a substrate and affinity label for diphosphopyridine nucleotide dependent isocitrate dehydrogenase.

作者信息

Bednar R A, Hartman F C, Colman R F

出版信息

Biochemistry. 1982 Jul 20;21(15):3681-9. doi: 10.1021/bi00258a025.

DOI:10.1021/bi00258a025

Abstract

摘要

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3,4-Didehydro-2-ketoglutarate: an affinity label for diphosphopyridine nucleotide dependent isocitrate dehydrogenase.

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Affinity labeling of the allosteric ADP activation site of NAD-dependent isocitrate dehydrogenase by 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-diphosphate.6-(4-溴-2,3-二氧代丁基)硫代腺苷5'-二磷酸对烟酰胺腺嘌呤二核苷酸依赖的异柠檬酸脱氢酶变构ADP激活位点的亲和标记

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The role of dissimilar subunits of NAD-specific isocitrate dehydrogenase from pig heart. Evaluation using affinity labeling.猪心脏中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶不同亚基的作用。亲和标记法评估

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Inactivation of pig heart NADP-specific isocitrate dehydrogenase by two affinity reagents is due to reaction with a cysteine not essential for function.

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Effect of arginine modification on the catalytic activity and allosteric activation by adenosine diphosphate of the diphosphopyridine nucleotide specific isocitrate dehydrogenase of pig heart.精氨酸修饰对猪心脏二磷酸吡啶核苷酸特异性异柠檬酸脱氢酶催化活性及二磷酸腺苷变构激活作用的影响。

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