哺乳动物交感神经节中慢抑制性突触后电位的药理特性及单胺能介导作用。
Pharmacological properties and monoaminergic mediation of the slow IPSP, in mammalian sympathetic ganglion.
作者信息
Ashe J H, Libet B
出版信息
Brain Res. 1982 Jun 24;242(2):345-9. doi: 10.1016/0006-8993(82)90321-3.
PMID:7116140
Abstract
Phenoxybenzamine can selectively eliminate the s-IPSP, in the presence of anti-cholinesterases that enhance s-IPSP and s-EPSP; and the alpha 2-antagonist, yohimbine, can partially but consistently depress s-IPSP selectively. The results provide positive pharmacological support for the monoaminergic nature of the transmitter for s-IPSP in mammalian sympathetic ganglia and argue against suggestions that the s-IPSP is a direct hyperpolarizing response to acetylcholine.
摘要
在存在增强慢抑制性突触后电位（s-IPSP）和慢兴奋性突触后电位（s-EPSP）的抗胆碱酯酶的情况下，酚苄明可选择性消除s-IPSP；而α2拮抗剂育亨宾可部分但持续地选择性抑制s-IPSP。这些结果为哺乳动物交感神经节中s-IPSP递质的单胺能性质提供了积极的药理学支持，并反驳了关于s-IPSP是对乙酰胆碱的直接超极化反应的观点。
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