Jeftinija S, Murase K, Nedeljkov V, Randic M
Brain Res. 1982 Jul 8;243(1):158-64. doi: 10.1016/0006-8993(82)91131-3.
Vasoactive intestinal polypeptide (VIP) applied by iontophoresis and/or pressure microinjection causes a strong excitation of more than 75% of all tested spinal neurons in laminae I-VII of both the cat intact spinal cord and the rat spinal cord slice preparation. In the cat intact spinal cord the excitation is not limited to a single population of neurons but is observed in all categories of units recognized in spinal preparations of cats in this area on the basis of their excitability by different kinds of cutaneous afferent input. In the rat spinal cord slice preparation, VIP depolarized dorsal horn neurons and increased their excitability. The depolarization was associated with a decrease in neuronal input resistance. These results are consistent with the possibility that VIP may have a physiological role in synaptic function, either as a transmitter or as a modulator.
通过离子电渗疗法和/或压力微注射施加的血管活性肠肽（VIP）可强烈兴奋猫完整脊髓和大鼠脊髓切片标本I-VII层中超过75%的所有受试脊髓神经元。在猫完整脊髓中，这种兴奋并不局限于单一神经元群体，而是在该区域猫脊髓标本中根据不同类型皮肤传入输入的兴奋性所识别的所有神经元类别中都能观察到。在大鼠脊髓切片标本中，VIP使背角神经元去极化并增加其兴奋性。这种去极化与神经元输入电阻的降低有关。这些结果与VIP可能在突触功能中作为递质或调节剂发挥生理作用的可能性是一致的。
