• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

降钙素基因相关肽的离子电渗疗法可使猫腰髓背角神经元产生缓慢而持久的兴奋。

Iontophoretic application of calcitonin gene-related peptide produces a slow and prolonged excitation of neurons in the cat lumbar dorsal horn.

作者信息

Miletic V, Tan H

机构信息

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.

出版信息

Brain Res. 1988 Apr 12;446(1):169-72. doi: 10.1016/0006-8993(88)91310-8.

DOI:10.1016/0006-8993(88)91310-8
PMID:3259448
Abstract

Calcitonin gene-related peptide (CGRP) was applied by iontophoresis onto physiologically characterized neurons. CGRP (20-100 nA) activated both wide-dynamic-range (5/8) and low-threshold mechanoreceptive units (3/12), but had no effect on nociceptive-specific neurons (0/4). The excitation was of slow onset (30 s to 3 min) and prolonged duration (up to 10 min). In none of the tested units did CGRP cause inhibition. The slow and prolonged action suggests a neuromodulatory role for CGRP in spinal cord sensory processes.

摘要

通过离子电渗法将降钙素基因相关肽（CGRP）施加于具有生理学特征的神经元上。CGRP（20 - 100纳安）激活了宽动态范围神经元（5/8）和低阈值机械感受单位（3/12），但对伤害性特异性神经元无影响（0/4）。兴奋起效缓慢（30秒至3分钟）且持续时间延长（长达10分钟）。在所测试的单位中，CGRP均未引起抑制作用。这种缓慢且持久的作用表明CGRP在脊髓感觉过程中具有神经调节作用。

相似文献

1
Iontophoretic application of calcitonin gene-related peptide produces a slow and prolonged excitation of neurons in the cat lumbar dorsal horn.降钙素基因相关肽的离子电渗疗法可使猫腰髓背角神经元产生缓慢而持久的兴奋。
Brain Res. 1988 Apr 12;446(1):169-72. doi: 10.1016/0006-8993(88)91310-8.
2
Actions of calcitonin gene-related peptide on rat spinal dorsal horn neurons.降钙素基因相关肽对大鼠脊髓背角神经元的作用。
Brain Res. 1988 Feb 16;441(1-2):357-61. doi: 10.1016/0006-8993(88)91414-x.
3
Facilitatory role of calcitonin gene-related peptide (CGRP) on excitation induced by substance P (SP) and noxious stimuli in rat spinal dorsal horn neurons. An iontophoretic study in vivo.降钙素基因相关肽（CGRP）对大鼠脊髓背角神经元中P物质（SP）诱导的兴奋及伤害性刺激的促进作用。一项体内离子电泳研究。
Brain Res. 1991 Sep 20;559(2):352-6. doi: 10.1016/0006-8993(91)90024-p.
4
Role of calcitonin gene-related peptide and its antagonist on the evoked discharge frequency of wide dynamic range neurons in the dorsal horn of the spinal cord in rats.降钙素基因相关肽及其拮抗剂对大鼠脊髓背角广动力范围神经元诱发放电频率的作用
Regul Pept. 2002 Jan 15;103(1):23-7. doi: 10.1016/s0167-0115(01)00326-3.
5
Analysis of calcitonin gene-related peptide-like immunoreactivity in the cat dorsal spinal cord and dorsal root ganglia provide evidence for a multisegmental projection of nociceptive C-fiber primary afferents.对猫脊髓背侧和背根神经节中降钙素基因相关肽样免疫反应性的分析为伤害性C纤维初级传入神经的多节段投射提供了证据。
J Comp Neurol. 1990 Dec 15;302(3):562-74. doi: 10.1002/cne.903020312.
6
Vasoactive intestinal polypeptide excites mammalian dorsal horn neurons both in vivo and in vitro.血管活性肠肽在体内和体外均能兴奋哺乳动物的背角神经元。
Brain Res. 1982 Jul 8;243(1):158-64. doi: 10.1016/0006-8993(82)91131-3.
7
5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons.5-羟色胺1A受体介导延髓脊髓5-羟色胺系统对脊髓背角伤害性神经元的作用。
Pharmacology. 1994 Jan;48(1):1-10. doi: 10.1159/000139156.
8
Purine-induced depression of dorsal horn neurons in the cat spinal cord: enhancement by tachykinins.嘌呤诱导猫脊髓背角神经元抑制：速激肽增强作用
Neuroscience. 1987 Dec;23(3):903-15. doi: 10.1016/0306-4522(87)90167-9.
9
Calcitonin gene-related peptide immunoreactivity in the cat lumbosacral spinal cord and the effects of multiple dorsal rhizotomies.猫腰骶脊髓中降钙素基因相关肽免疫反应性及多次背根切断术的影响
J Comp Neurol. 1989 Sep 8;287(2):225-37. doi: 10.1002/cne.902870206.
10
Morphine does not reduce the intraspinal release of calcitonin gene-related peptide in the cat.吗啡不会降低猫脊髓内降钙素基因相关肽的释放。
Neurosci Lett. 1990 Sep 18;117(3):319-24. doi: 10.1016/0304-3940(90)90684-2.

引用本文的文献

1
Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine.揭示降钙素基因相关肽与谷氨酸之间的关系：从偏头痛的外周兴奋到中枢敏化
J Headache Pain. 2025 May 6;26(1):101. doi: 10.1186/s10194-025-02043-x.
2
The role of erenumab in the treatment of migraine.erenumab在偏头痛治疗中的作用。
Ther Adv Neurol Disord. 2020 May 27;13:1756286420927119. doi: 10.1177/1756286420927119. eCollection 2020.
3
Pulsed Radiofrequency Applied to the Sciatic Nerve Improves Neuropathic Pain by Down-regulating The Expression of Calcitonin Gene-related Peptide in the Dorsal Root Ganglion.
脉冲射频作用于坐骨神经通过下调背根神经节降钙素基因相关肽的表达改善神经病理性疼痛。
Int J Med Sci. 2018 Jan 1;15(2):153-160. doi: 10.7150/ijms.20501. eCollection 2018.
4
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis?降钙素基因相关肽受体拮抗剂：超越偏头痛疼痛——骨关节炎的一种潜在镇痛策略？
Curr Pain Headache Rep. 2013 Nov;17(11):375. doi: 10.1007/s11916-013-0375-2.
5
Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms.Mas相关基因（Mrg）受体通过直接和间接机制对弗氏完全佐剂诱导炎症大鼠痛觉过敏的影响。
Br J Pharmacol. 2013 Nov;170(5):1027-40. doi: 10.1111/bph.12326.
6
Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons.感觉神经元中 collapsin 反应介质蛋白-2 (CRMP-2) 对 N 型电压门控钙通道 (Cav2.2) 和递质释放的调节作用。
J Cell Sci. 2009 Dec 1;122(Pt 23):4351-62. doi: 10.1242/jcs.053280. Epub 2009 Nov 10.
7
Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons.胶质细胞系源性神经营养因子家族配体增强辣椒素刺激的感觉神经元中降钙素基因相关肽的释放。
Neuroscience. 2009 Jun 16;161(1):148-56. doi: 10.1016/j.neuroscience.2009.03.006. Epub 2009 Mar 11.
8
Extreme tolerance to ammonia fumes in African naked mole-rats: animals that naturally lack neuropeptides from trigeminal chemosensory nerve fibers.非洲裸鼹鼠对氨气烟雾的超强耐受性：天生缺乏三叉神经化学感觉神经纤维中神经肽的动物。
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 May;195(5):419-27. doi: 10.1007/s00359-009-0420-0. Epub 2009 Feb 15.
9
Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain.保留的初级传入神经元在神经性疼痛发病机制中的作用。
Mol Neurobiol. 2002 Aug;26(1):57-67. doi: 10.1385/MN:26:1:057.
10
Neurotransmitters in subcortical somatosensory pathways.皮层下躯体感觉通路中的神经递质。
Anat Embryol (Berl). 1994 Mar;189(3):181-214. doi: 10.1007/BF00239008.