组胺和戊巴比妥对垂体切除大鼠血浆和脑脊液中血管加压素水平的影响。

Influence of histamine and pentobarbitone on plasma and CSF vasopressin levels of hypophysectomized rats.

作者信息

Mens W B, Van Dam A F, Van Wimersma Greidanus T B

出版信息

Brain Res Bull. 1982 May;8(5):555-7. doi: 10.1016/0361-9230(82)90016-8.

Abstract

Histamine increased vasopressin levels, as measured by radioimmunoassay (RIA), in both cerebrospinal fluid (CSF) and plasma of hypophysectomized rats, while histamine enhanced plasma but not CSF levels of vasopressin in sham operated rats. Pentobarbitone increased CSF vasopressin levels in hypophysectomized rats and in sham operated animals. The present data demonstrate that the histamine induced elevation of vasopressin levels in the blood is only temporarily disturbed after hypophysectomy, while the effect of histamine on CSF vasopressin levels of hypophysectomized rats is of a more permanent nature.

摘要

通过放射免疫分析法（RIA）测定，组胺可使垂体切除大鼠的脑脊液（CSF）和血浆中的血管加压素水平升高，而组胺仅使假手术大鼠的血浆血管加压素水平升高，对脑脊液中的血管加压素水平无影响。戊巴比妥可使垂体切除大鼠和假手术动物的脑脊液血管加压素水平升高。目前的数据表明，垂体切除后，组胺诱导的血液中血管加压素水平升高只是暂时受到干扰，而组胺对垂体切除大鼠脑脊液血管加压素水平的影响则更为持久。