放线菌酮和链霉抗生物素A对大鼠蛋白质合成及胃液分泌的影响。

Effects of cycloheximide and streptovitacin A on protein synthesis and gastric secretion in rats.

作者信息

Cihák A, Korbová L, Kohout J

出版信息

J Antibiot (Tokyo). 1978 Sep;31(9):902-5. doi: 10.7164/antibiotics.31.902.

DOI:10.7164/antibiotics.31.902

Abstract

Cycloheximide and streptovitacin A administered in vivo to rats display a similar dual effect on the labelling of soluble liver proteins by valine-14C, and result in a similar enhancement of liver uridine kinase activity. On the other hand, in pylorus-ligated rats, both antibiotics markedly depress gastric secretion, acid output, and the level of mucoproteins and proteolytic activity in secreted juice. Streptovitacin A on a molar basis was in all cases 5 approximately 8 times more effective than cycloheximide.

摘要

给大鼠体内注射放线菌酮和链霉抗生物素蛋白A，对缬氨酸-14C标记可溶性肝蛋白显示出类似的双重作用，并导致肝尿苷激酶活性出现类似增强。另一方面，在幽门结扎的大鼠中，这两种抗生素均显著抑制胃液分泌、胃酸分泌以及分泌液中粘蛋白水平和蛋白水解活性。按摩尔计算，链霉抗生物素蛋白A在所有情况下的效力约为放线菌酮的5至8倍。