Cihák A, Korbová L, Kohout J
J Antibiot (Tokyo). 1978 Sep;31(9):902-5. doi: 10.7164/antibiotics.31.902.
Cycloheximide and streptovitacin A administered in vivo to rats display a similar dual effect on the labelling of soluble liver proteins by valine-14C, and result in a similar enhancement of liver uridine kinase activity. On the other hand, in pylorus-ligated rats, both antibiotics markedly depress gastric secretion, acid output, and the level of mucoproteins and proteolytic activity in secreted juice. Streptovitacin A on a molar basis was in all cases 5 approximately 8 times more effective than cycloheximide.
给大鼠体内注射放线菌酮和链霉抗生物素蛋白A，对缬氨酸-14C标记可溶性肝蛋白显示出类似的双重作用，并导致肝尿苷激酶活性出现类似增强。另一方面，在幽门结扎的大鼠中，这两种抗生素均显著抑制胃液分泌、胃酸分泌以及分泌液中粘蛋白水平和蛋白水解活性。按摩尔计算，链霉抗生物素蛋白A在所有情况下的效力约为放线菌酮的5至8倍。
