针对免疫动物同源蛋白中相同蛋白质抗原位点的抗体。兔体内抗抹香鲸肌红蛋白抗体的自身反应性。
Antibodies against protein antigenic sites that are identical in the homologous protein of the immunized animal. Autoreactivity in rabbits of antibodies to sperm-whale myoglobin.
作者信息
Kazim A L, Atassi M Z
出版信息
Biochim Biophys Acta. 1977 Sep 27;494(1):277-82. doi: 10.1016/0005-2795(77)90156-8.
PMID:71166
Abstract
Sequence comparisons between the antigenic sites of sperm-whale myoglobin and the corresponding regions in rabbit myoglobin indicate that rabbits make antibodies to regions of the sperm-whale myoglobin molecule which are identical to the corresponding regions in rabbit myoglobin. Rabbit myoglobin did not precipitate with antisera to sperm-whale myoglobin. However, it exhibited an extensive cross-reaction as demonstrated by its ability to inhibit the precipitin reaction of sperm-whale myoglobin, and on an immunoadsorbent, bound a large amount of antibodies to sperm-whale myoglobin.
摘要
抹香鲸肌红蛋白抗原位点与兔肌红蛋白相应区域之间的序列比较表明，兔子会针对抹香鲸肌红蛋白分子中与兔肌红蛋白相应区域相同的区域产生抗体。兔肌红蛋白不能与抗抹香鲸肌红蛋白的抗血清发生沉淀反应。然而，它表现出广泛的交叉反应，如抑制抹香鲸肌红蛋白沉淀反应的能力所证明，并且在免疫吸附剂上能结合大量抗抹香鲸肌红蛋白的抗体。
相似文献
1
Antibodies against protein antigenic sites that are identical in the homologous protein of the immunized animal. Autoreactivity in rabbits of antibodies to sperm-whale myoglobin.针对免疫动物同源蛋白中相同蛋白质抗原位点的抗体。兔体内抗抹香鲸肌红蛋白抗体的自身反应性。
Biochim Biophys Acta. 1977 Sep 27;494(1):277-82. doi: 10.1016/0005-2795(77)90156-8.
2
The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species.对肌红蛋白的抗体反应与免疫物种无关。分析了在不同物种中产生的十五种肌红蛋白与抹香鲸肌红蛋白抗血清交叉反应的抗原位点和环境残基中的替换情况。
Biochem J. 1980 Dec 1;191(3):681-97. doi: 10.1042/bj1910681.
3
First consequences of the determination of the entire antigenic structure of sperm-whale myoglobin.抹香鲸肌红蛋白完整抗原结构测定的初步结果。
Adv Exp Med Biol. 1978;98:19-40. doi: 10.1007/978-1-4615-8858-0_3.
4
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Use of immunoadsorbents for the study of antibody binding to sperm whale myoglobin and its synthetic antigenic sites.免疫吸附剂在研究抗体与抹香鲸肌红蛋白及其合成抗原位点结合中的应用。
J Immunol Methods. 1979;30(2):139-51. doi: 10.1016/0022-1759(79)90088-7.
7
The antibody response to myoglobin--I. Systematic synthesis of myoglobin peptides reveals location and substructure of species-dependent continuous antigenic determinants.针对肌红蛋白的抗体反应——I. 肌红蛋白肽段的系统合成揭示了物种依赖性连续抗原决定簇的位置和亚结构。
Mol Immunol. 1986 Jun;23(6):603-10. doi: 10.1016/0161-5890(86)90096-9.
8
Time-dependent study of the antibody response to sperm-whale myoglobin: recognition of the antigenic sites is unaltered over an extended period of immunization.针对抹香鲸肌红蛋白抗体反应的时间依赖性研究：在长时间免疫过程中抗原位点的识别未发生改变。
Mol Immunol. 1981 Jun;18(6):473-9. doi: 10.1016/0161-5890(81)90124-3.
9
Topographic antigenic determinants recognized by monoclonal antibodies to sperm whale myoglobin.抹香鲸肌红蛋白单克隆抗体识别的拓扑抗原决定簇。
J Biol Chem. 1982 Mar 25;257(6):3189-98.
10
Immunochemistry of sperm-whale myoglobin--XXII. Accurate delineation of the single reactive region in sequence 103-120 by immunochemical studies of synthetic peptides: the complete antigenic structure of the protein.抹香鲸肌红蛋白的免疫化学——XXII. 通过合成肽的免疫化学研究精确描绘序列103 - 120中的单一反应区域：蛋白质的完整抗原结构
Immunochemistry. 1975 Sep;12(9):735-40.
引用本文的文献
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Structurally inherent antigenic sites. Localization of the antigenic sites of the alpha-chain of human haemoglobin in three host species by a comprehensive synthetic approach.结构上固有的抗原位点。通过综合合成方法在三种宿主物种中定位人血红蛋白α链的抗原位点。
Biochem J. 1982 Apr 1;203(1):201-8. doi: 10.1042/bj2030201.
2
The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species.对肌红蛋白的抗体反应与免疫物种无关。分析了在不同物种中产生的十五种肌红蛋白与抹香鲸肌红蛋白抗血清交叉反应的抗原位点和环境残基中的替换情况。
Biochem J. 1980 Dec 1;191(3):681-97. doi: 10.1042/bj1910681.
3
Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites.蛋白质抗原结构的精确测定揭示了蛋白质的分子免疫识别，并为其他蛋白质结合位点的合成模拟提供了原型。
Mol Cell Biochem. 1980 Aug 29;32(1):21-43. doi: 10.1007/BF00421293.
4
Antigenic structure of human haemoglobin. Localization of the antigenic sites of the beta-chain in three host species by synthetic overlapping peptides representing the entire chain.人血红蛋白的抗原结构。通过代表整条β链的合成重叠肽在三种宿主物种中定位β链的抗原位点。
Biochem J. 1986 Mar 1;234(2):441-7. doi: 10.1042/bj2340441.
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