Sakaguchi T, Shimojo E
J Physiol. 1984 Jun;351:573-81. doi: 10.1113/jphysiol.1984.sp015263.
Intragastric pressures were recorded in bilaterally adrenalectomized male rats with insulin hypoglycaemia. A significant depression in intragastric pressure was noted following the administration of D-glucose injected into the hepatic portal vein but not after the administration of L-glucose, D-mannose, D-fructose, D-galactose, D-xylose or D-arabinose. The reduction in intragastric pressure induced by the portal administration of D-glucose was not reproduced following selective division of the hepatic branch of the vagus nerve. Of the three anomeric forms of D-glucose used (alpha-D-glucose, equilibrated D-glucose and beta-D-glucose), beta-D-glucose was most potent in reducing the intragastric pressure. These results suggest that the vagal afferents may convey information concerning glucose concentration in the portal vein to the central nervous system, and that the activation of such afferents may modulate gastric motility which is dependent on the anomeric stereospecificity of D-glucose.
记录了双侧肾上腺切除的雄性大鼠在胰岛素低血糖状态下的胃内压。向肝门静脉注射D-葡萄糖后，胃内压出现显著降低，但注射L-葡萄糖、D-甘露糖、D-果糖、D-半乳糖、D-木糖或D-阿拉伯糖后未出现这种情况。选择性切断迷走神经肝支后，门静脉注射D-葡萄糖引起的胃内压降低未再现。在所使用的三种D-葡萄糖异头物形式（α-D-葡萄糖、平衡D-葡萄糖和β-D-葡萄糖）中，β-D-葡萄糖在降低胃内压方面最有效。这些结果表明，迷走神经传入纤维可能将门静脉中葡萄糖浓度的信息传递给中枢神经系统，并且此类传入纤维的激活可能调节依赖于D-葡萄糖异头物立体特异性的胃动力。
