Higashi A, Ikeda T, Uehara I, Matsuda I
Eur J Pediatr. 1982 May;138(3):237-40. doi: 10.1007/BF00441209.
The zinc (Zn) content of commercially available formula milks in Japan is less than that of breast milk obtained during the first three months of lactation, but is similar to that at five months of lactation. The copper (Cu) content of the formula milks is much lower than that of breast milk obtained during the five months. These two trace elements were measured in serum (at birth, one, three, and five months of age), hair (at birth and at five months of age) and urine (at one, three and five months of age) of twenty-one breast fed and twenty formula fed full term infants. Despite the differences in Zn and Cu intakes, these parameters were similar in these two infant groups, except for urinary Zn at one and three months of age. These were significantly higher in breast fed infants (P less than 0.005 and P less than 0.05). Weight and length increments were not different in either infant group. It appeared that normal, full term infants tolerated low-content Zn and Cu formula milks well. This observation, however, is not at variance with the FAO/WHO recommendation for prevention of Zn and Cu deficiency.
日本市售配方奶中的锌（Zn）含量低于哺乳期前三个月的母乳，但与哺乳期五个月时的母乳相似。配方奶中的铜（Cu）含量远低于五个月母乳中的铜含量。对21名母乳喂养的足月婴儿和20名配方奶喂养的足月婴儿的血清（出生时、1个月、3个月和5个月时）、头发（出生时和5个月时）和尿液（1个月、3个月和5个月时）中的这两种微量元素进行了测量。尽管锌和铜的摄入量存在差异，但除了1个月和3个月时的尿锌外，这两组婴儿的这些参数相似。母乳喂养婴儿的尿锌显著更高（P<0.005和P<0.05）。两组婴儿的体重和身长增长没有差异。看来正常足月婴儿能很好地耐受低锌和低铜配方奶。然而，这一观察结果与粮农组织/世卫组织预防锌和铜缺乏的建议并不矛盾。
