Nishiyama S, Nakamura T, Higashi A, Matsuda I
Department of Pediatrics, Kumamoto University Medical School, Japan.
Calcif Tissue Int. 1991 Sep;49(3):179-82. doi: 10.1007/BF02556114.
Serum concentrations of ionized calcium, parathyroid hormone, and calcitonin were measured during zinc infusion in patients of short stature (n = 15); those with insulin-dependent diabetes mellitus (n = 13); and age-matched controls (n = 10). The increase in serum zinc concentrations after zinc infusion resulted in a decrease in the serum calcitonin concentrations but not in concentrations of ionized calcium and parathyroid hormone. A significant negative correlation was obtained between body zinc clearances and decreases in serum calcitonin levels at 60 minutes after the infusion of zinc. Thus, we found a relationship between infusion of zinc and the regulation of calcitonin secretion. We propose that an increase in the serum zinc pool plays a definite role in inhibiting calcitonin secretion from thyroid tissue.
在身材矮小的患者（n = 15）、胰岛素依赖型糖尿病患者（n = 13）以及年龄匹配的对照组（n = 10）中，在输注锌的过程中测量了血清离子钙、甲状旁腺激素和降钙素的浓度。输注锌后血清锌浓度的升高导致血清降钙素浓度降低，但离子钙和甲状旁腺激素的浓度未降低。在输注锌60分钟后，机体锌清除率与血清降钙素水平的降低之间存在显著的负相关。因此，我们发现了锌输注与降钙素分泌调节之间的关系。我们认为血清锌池的增加在抑制甲状腺组织降钙素分泌中起一定作用。
