A study to ascertain whether hydrocortisone 17-butyrate (Locoid) 0.1% cream has any effect on the hypothalamic-pituitary-adrenal axis in children with skin diseases.

A study was conducted in eight children requiring topical corticosteroid treatment for dermatological disorders. The trial was carried out with hydrocortisone 17-butyrate (Locoid) 0.1% cream. The children were treated twice daily with Locoid cream applied to areas involving at least 20% of the body surface for a period of 2 to 3 weeks. Statistical analysis did not reveal any significant changes in plasma cortisol levels after treatment compared to pre-treatment baseline levels. No side-effects were reported.