Watanabe H K, Hashimoto Y, Abe I, Sato H
Gan. 1982 Feb;73(1):136-40.
The carcinogenicities of 2-methoxy-4-aminoazobenzene and 3-methoxy-4-aminoazobenzene (2-MeO-AAB and 3-MeO-AAB) and their N-hydroxy derivatives (N-OH-2-MeO-AAB and N-OH-3-MeO-AAB) were tested in (C3H X C57BL/6) F1 mice. Topical sc injections, twice weekly for 8 weeks, of 4 or 8 mumol of N-OH-3-MeO-AAB dissolved in 0.1 ml of olive oil containing 10% dimethyl sulfoxide induced fibrosarcomas at the site of application. Similar treatment with 3-MeO-AAB or 2-MeO-AAB as well as N-OH-2-MeO-AAB failed to induce sarcomas. Oral administration of 0.09% 3-MeO-AAB in the diet for 13 months induced hepatic tumors in female mice but not in males. 2-MeO-AAB did not induce tumors in male or female mice. The relationship between carcinogenicity, mutagenicity, the ability to induce unscheduled DNA synthesis, and the metabolism of these azo dyes is discussed.
在（C3H×C57BL/6）F1小鼠中测试了2-甲氧基-4-氨基偶氮苯和3-甲氧基-4-氨基偶氮苯（2-MeO-AAB和3-MeO-AAB）及其N-羟基衍生物（N-OH-2-MeO-AAB和N-OH-3-MeO-AAB）的致癌性。将4或8微摩尔溶于含10%二甲基亚砜的0.1毫升橄榄油中的N-OH-3-MeO-AAB每周两次皮下注射8周，在注射部位诱发了纤维肉瘤。用3-MeO-AAB或2-MeO-AAB以及N-OH-2-MeO-AAB进行类似处理未能诱发肉瘤。在饲料中口服0.09%的3-MeO-AAB 13个月，雌性小鼠诱发了肝肿瘤，但雄性小鼠未诱发。2-MeO-AAB在雄性或雌性小鼠中均未诱发肿瘤。讨论了这些偶氮染料的致癌性、致突变性、诱导非程序性DNA合成的能力与代谢之间的关系。
