Hornnes P J, Kühl C, Lauritsen K B
Horm Metab Res. 1982 Jul;14(7):335-8. doi: 10.1055/s-2007-1019011.
The gastro-entero-pancreatic (GEP) hormone response to glucose ingestion is considerably altered in pregnancy in normal women and gestational diabetics. In normal women, also the GEP hormone response to protein is changed in pregnancy. In the present investigation, the gastrin, gastric inhibitory polypeptide (GIP), gut glucagon-like-immunoreactivity (gut GLI), insulin, pancreatic glucagon, and pancreatic polypeptide (PP) responses to a protein rich meal in pregnancy and postpartum were studied in 10 women with gestational diabetes. Five of the women were overweight and five were normal weight. Fasting and postprandial gut GLI and PP levels were reduced and insulin levels enhanced in pregnancy. No effect of pregnancy on fasting or postprandial gastrin, GIP, or glucagon levels was found. In pregnancy as well as postpartum, insulin levels were higher in the overweight than in the normal weight patients, whereas the concentrations of the other hormones were similar in the two subgroups of gestational diabetics. It is concluded that the GEP hormone response to a protein rich meal is influenced by late pregnancy in gestational diabetics in the same way as in normal women. The physiological consequences of the findings are not known in detail as yet but they may be important to carbohydrate metabolism and gastrointestinal physiology in pregnancy.
在正常女性和妊娠糖尿病患者中，胃肠道胰腺（GEP）激素对葡萄糖摄入的反应在孕期会发生显著改变。在正常女性中，GEP激素对蛋白质的反应在孕期也会发生变化。在本研究中，对10名妊娠糖尿病女性在孕期和产后对富含蛋白质餐食的胃泌素、胃抑制性多肽（GIP）、肠胰高血糖素样免疫反应性（肠GLI）、胰岛素、胰高血糖素和胰多肽（PP）反应进行了研究。其中5名女性超重，5名体重正常。孕期空腹和餐后肠GLI及PP水平降低，胰岛素水平升高。未发现孕期对空腹或餐后胃泌素、GIP或胰高血糖素水平有影响。在孕期和产后，超重患者的胰岛素水平高于体重正常患者，而妊娠糖尿病两个亚组中其他激素的浓度相似。结论是，妊娠糖尿病患者在妊娠晚期对富含蛋白质餐食的GEP激素反应与正常女性一样受到影响。这些发现的生理后果目前尚不完全清楚，但它们可能对孕期碳水化合物代谢和胃肠道生理很重要。
