大鼠网织红细胞从大鼠血浆转铁蛋白摄取铁。
Iron uptake from rat plasma transferrin by rat reticulocytes.
作者信息
Huebers H, Huebers E, Csiba E, Finch C A
出版信息
J Clin Invest. 1978 Nov;62(5):944-51. doi: 10.1172/JCI109223.
Abstract
Fast and slow rat transferrins were isolated by isoelectric focusing and prepared in their di- and monoferric forms. A comparison of the rates of iron release between fast and slow monoferric transferrins when incubated with reticulocytes or injected in vivo showed no significant difference in the behavior of the two isotransferrin species. Reticulocyte uptake of diferric transferrin resulted in the removal of both iron atoms from the transferrin molecule. A twofold greater iron uptake was observed from diferric as compared with monoferric iron, provided reticulocyte receptors were saturated. It is concluded that the two species of transferrin and their individual sites function similarly in their release of iron to tissue receptors.
摘要
通过等电聚焦分离出快型和慢型大鼠转铁蛋白，并制备其二价铁和一价铁形式。将快型和慢型一价铁转铁蛋白与网织红细胞一起孵育或体内注射时，比较它们的铁释放速率，结果表明这两种同型转铁蛋白的行为没有显著差异。二价铁转铁蛋白被网织红细胞摄取后，转铁蛋白分子中的两个铁原子都会被去除。如果网织红细胞受体饱和，与一价铁相比，二价铁的铁摄取量会高出两倍。结论是，这两种转铁蛋白及其各自的位点在向组织受体释放铁的过程中功能相似。
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