Fristrom D K
J Cell Biol. 1982 Jul;94(1):77-87. doi: 10.1083/jcb.94.1.77.
The organization of septate junctions during morphogenesis of imaginal disks is described from freeze-fracture replicas and thin sections with a view to understanding junction modulation during rearrangements of cells in epithelia. The septate junctions of each epithelial cell of the disk are distributed in a number of discrete domains equal to the number of neighboring cells. Individual septa traverse domains of contact between pairs of adjacent cells, turn downwards at the lateral boundary of the domain and run parallel to the intersection with a third cell. This arrangement leaves small channels at three-cell intersections that are occupied by specialized structures termed "tricellular plugs." Cell rearrangement involves a progressive change in the width of contact domains between adjacent cells, until old contacts are broken and new ones established. It is proposed that the septate junction adjusts to the changing width of domains by the compaction or extension of existing septa. This redistribution of septa theoretically allows a transepithelial barrier to be maintained during cell rearrangements. The applicability of this model to other epithelial tissues is discussed.
通过冷冻断裂复制品和超薄切片描述了成虫盘形态发生过程中分隔连接的组织情况，旨在了解上皮细胞重排过程中的连接调节。盘状结构中每个上皮细胞的分隔连接分布在多个离散区域，其数量与相邻细胞的数量相等。单个隔膜穿过相邻细胞对之间的接触区域，在区域的侧向边界处向下弯曲，并与第三个细胞的交点平行延伸。这种排列在三细胞交点处留下小通道，这些通道被称为“三细胞栓”的特殊结构占据。细胞重排涉及相邻细胞之间接触区域宽度的逐渐变化，直到旧的接触被打破，新的接触建立。有人提出，分隔连接通过现有隔膜的压实或延伸来适应区域宽度的变化。隔膜的这种重新分布理论上允许在细胞重排过程中维持跨上皮屏障。讨论了该模型在其他上皮组织中的适用性。
