McDonald A J
J Comp Neurol. 1982 Jul 10;208(4):401-18. doi: 10.1002/cne.902080409.
Since recent studies indicate that distinct neuropeptides and projections are associated with discrete portions of the central amygdaloid nucleus (CN), a detailed investigation of the cytoarchitecture of CN should contribute to an understanding of its organization. Qualitative and quantitative analyses of the rat CN using Nissl, Klüver-Barrera, and Golgi techniques suggests that it consists of four subdivisions. The medial subdivision (CM), which is closely associated with the stria terminalis, is narrow caudally but enlarges near the rostral pole of CN. Most neurons in CM have long dendrites that branch sparingly and have a moderate number of dendritic spines. A smaller number of CM neurons have thick dendrites with virtually no spines. Lateral to CM is the lateral subdivision (CL) which appears round in coronal sections. Neurons of CL have a very dense covering of dendritic spines and resemble medium-size spiny neurons of the striatum. Area X of Hall contains spiny neurons similar to those of CL and spine-sparse neurons that resemble medium-size spine-sparse cells of the striatum. Since area X encapsulates the lateral aspect of CL, it is termed the lateral capsular subdivision (CLC) of CN. The lateral capsular subdivision enlarges rostrally and is divided into dorsal and ventral portions by a laminar extension of the putamen. Near the rostral pole of CN a small region of tightly packed, intensely stained neurons is interposed between CL and CM. Golgi preparations reveal that this intermediate subdivision (CI) of CN contains neurons similar to those of CM. The lateral subdivision, CLC, and CM correspond, in part, to subdivisions recognized in previous Nissl studies. The intermediate subdivision has not been recognized as a distinct subdivision in previous investigations. This is the first Golgi study to recognize differences in neuronal morphology in particular subdivisions of the rat CN. The correlation of Nissl and Golgi preparations has permitted a more accurate determination of the boundaries and total extent of each subdivision than the use of Nissl techniques alone.
由于最近的研究表明，不同的神经肽和投射与杏仁中央核（CN）的不同部分相关，因此对CN细胞结构的详细研究应有助于理解其组织结构。使用尼氏染色法、克吕弗-巴雷拉染色法和高尔基染色法对大鼠CN进行的定性和定量分析表明，它由四个亚区组成。内侧亚区（CM）与终纹紧密相连，在尾部较窄，但在CN的吻极附近扩大。CM中的大多数神经元有长树突，分支较少，有适量的树突棘。少数CM神经元有粗树突，几乎没有棘。CM外侧是外侧亚区（CL），在冠状切片中呈圆形。CL的神经元有非常密集的树突棘覆盖，类似于纹状体的中等大小多棘神经元。霍尔的X区包含与CL相似的多棘神经元和类似于纹状体中等大小少棘细胞的少棘神经元。由于X区包裹着CL的外侧，因此被称为CN的外侧囊亚区（CLC）。外侧囊亚区在吻侧扩大，并被壳核的层状延伸分为背侧和腹侧部分。在CN的吻极附近，一小群紧密排列、染色强烈的神经元介于CL和CM之间。高尔基染色制剂显示，CN的这个中间亚区（CI）包含与CM相似的神经元。外侧亚区、CLC和CM部分对应于先前尼氏染色研究中识别的亚区。中间亚区在先前的研究中未被识别为一个独特的亚区。这是第一项识别大鼠CN特定亚区神经元形态差异的高尔基染色研究。与单独使用尼氏染色技术相比，尼氏染色和高尔基染色制剂的相关性使得能够更准确地确定每个亚区的边界和总范围。
